Tachykinin receptors : diversity and unity.
نویسندگان
چکیده
منابع مشابه
Tachykinin receptors and airway pathophysiology.
The mammalian tachykinins (TKs), substance P and neurokinin A, are present in sensory nerve fibres in the upper and lower airways of various mammalian species, including humans. TKs are released from these afferent nerves in an "efferent" mode at peripheral level, especially in response to irritant stimuli. TKs exert a variety of biological effects (bronchoconstriction, plasma protein extravasa...
متن کاملTargeting tachykinin receptors in neuroblastoma
Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%. Adding targeted drugs to first-line therapy regimens is a promising approach to improve survival in these patients. TACR1 activation by substance P has been reported to be mitogenic in cancer cell lines. Tac...
متن کاملUnity in Diversity?
This article considers how well the existing sociological literature on immigrant integration and assimilation responds to public fears over multiculturalism. The current backlash against multiculturalism rests on both its perceived negative effects for immigrants’ socioeconomic integration and its failure to encourage civic and political cohesion. I offer a brief review of multiculturalism as ...
متن کاملPharmacology and Function of Tachykinin Receptors
The existence of SP was described in the 1930s by Von Euler and Gaddum in mammals, and tachykinin peptides were identified and sequenced by Erspamer in non-vertebrated (eledoisin) and then in nonmammalian species (physalaemin). In the 1960s Lembeck continued Von Euler and Gaddum’s studies, describing the effects of SP and other tachykinins in the central nervous system (CNS) and peripheral prep...
متن کاملDiversity and Unity of Modularity
Since the publication of Fodor's (1983) The Modularity of Mind, there have been quite a few discussions of cognitive modularity among cognitive scientists. Generally, in those discussions, modularity means a property of specialized cognitive processes or a domain-specific body of information. In actuality, scholars understand modularity in many different ways. Different characterizations of mod...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1989
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)43007-2